Jithin T JosephCTDS

Motor threshold assessment

ML-PEST CTDS

Record each response to update the MT estimate, next test intensity and live graphs. This tool works independently of the other CTDS pages.

How to use this toolRecord responses with RR CTDS or ML-PEST CTDS, or document an external result.
  1. Choose RR CTDS, ML-PEST CTDS or the external-result pathway. Select the hand or leg, muscle and response method; record the relevant device and coil details.
  2. Confirm preparation, the motor hotspot and a clinician-set output ceiling. Resting EMG and visual responses are distinct methods; use the method permitted by the applicable device protocol.
  3. For RR CTDS, set the starting intensity and mark each delivered pulse Yes or No. Review the block count and search suggestion; untested pulses remain untested. Follow the displayed bracketing and refinement process.
  4. For ML-PEST CTDS, choose the start and review plan, then record each delivered intensity and response. The estimate, next suggestion and graphs update from the observations; checkpoints are review points rather than confidence-based stopping rules.
  5. Review the result, response history, cautions and method reference before retaining it. Independent clinical validation of ML-PEST CTDS is pending; confirm its estimate independently before treatment. For an external result, record its original application, method and clinician review.
Open full user guide →
Clinical validation pending. Use as an evaluation aid and independently confirm MT before treatment. Estimates are not automatically accepted for treatment setup. Use trained supervision, hearing protection and device-specific limits; visual movement and EMG thresholds are distinct.

Simulation findings

Independent clinical validation pending

Results cover matching-model, broader-response and stress scenarios.

127,000Synthetic assessments
20- and 30-pulse plans
99.92%Within ±5 MSO points
Matching model assumptions · 6,000 runs
96.28%Within ±5 MSO points
Broader response models · 108,000 runs
How to interpret these results

Accuracy figures use 30 pulses and the default 7% model spread. ±5 MSO points is a descriptive simulation measure, not a clinical acceptance threshold; stress-test results and review-readiness limitations are reported on the results page.

ML-PEST CTDS matched MTAT outputs in 37 of 37 isolated numerical reference cases. Simulation accuracy was tested against known synthetic thresholds, not against MTAT. Similar overall performance to MTAT has not been demonstrated; independent clinical validation is pending.

View simulation methods, graphs and results →

1. Prepare

Equipment details (optional record)
Hand / leg preparation guidance
Hand hotspot search

For a focal figure-of-eight coil, Groppa describes an initial search region about 5 cm lateral and 0–1 cm anterior to the vertex. Refine using the contralateral muscle MEP. A posterolateral handle at approximately 45° is a conventional hand-M1 starting orientation; verify coil and waveform-specific current direction.

Support the hand and forearm, use the selected muscle’s surface EMG montage, inspect background relaxation, and compare nearby positions while keeping intensity and pose consistent.

Scalp map and coil orientation (optional record)

Mark the measured hotspot

Posterior / inionAnterior / nasionLRCzSchematic only · not patient-scaled

Negative lateral = patient left. Negative anterior = posterior. Grid spacing represents 1 cm in the record only; measure on the actual scalp. A selected dot is not proof of a hotspot.

Setup locks once trials are recorded. Reset before changing muscle, side, hotspot, coil or waveform.

2. Count responses

Advanced · model spread: 7% of MT

Default: 7%, following the Awiszus model. For MT = 40% MSO, this means a model response spread of 2.8% MSO. It is not a stopping tolerance or confidence interval. Other values are research settings. The 0.1–100% input limits are computational bounds, not a recommended clinical range. This setting locks when the run starts.

No previous MT is required. Review pauses at the selected pulse count; reaching that count alone does not establish accuracy.

Awaiting observations— % MSOEstimated resting MT

Method: ML-PEST CTDS · maximum-likelihood estimation.

0 / 30 valid observations

Choose the first test intensity within the device and patient-specific limits. The default is 37% MSO; every subsequent suggestion updates from the recorded responses.

Before starting
  • Confirm the hotspot, resting muscle and preparation checks
  • Set the clinician output ceiling

3. Review the result

Assessment not complete

Review after 30 valid pulses, with both positive and negative responses and no blocking flags.

Review the response history and equipment setup before accepting the estimate.

Review structured report ↓

Clinical TMS Decision Support and Placement Tool

Motor threshold

Draft for physician review

Threshold result and response method

  • ML-PEST CTDS — MOTOR THRESHOLD REPORT.
  • MT estimate: not yet available.
  • Status: Assessment incomplete / review required.
  • Assessment: right hand; APB; resting EMG response ≥50 µV peak-to-peak.

Recorded responses

  • Responses: 0 pulses; 0 positive, 0 negative. Review point: 30 pulses.
  • Next test intensity: paused for review. Output ceiling: not set% MSO.

Setup and verification

  • Preparation checks: not confirmed.

Limitations and review

  • REVIEW REQUIRED: Set an integer output ceiling between 1 and 100% MSO.
  • Method: maximum-likelihood sequential estimation; response spread 7% of candidate MT. No confidence interval is provided.
  • Evaluation estimate; clinical validation is pending. Independently confirm MT before treatment. This estimate is not automatically accepted for treatment setup.
  • References: Awiszus (2003), doi:10.1016/S1567-424X(09)70205-3; Mishory et al. (2004), doi:10.1097/00124509-200409000-00007.
CTDS · Clinician-led documentation

Summary of entered information; missing entries are not negative findings. Confirm completeness, method limitations, original guidance and device instructions before clinical use. Review status applies to each recorded stage, not automatic approval of the complete report.

Choose Save as PDF in the print dialog; turn off browser headers and footers. Use Full record for details and references.

← BackNext: coil setup →
Temporary assessment and clearing entries
Entries stay in this browser tab across pages and refreshes. No patient identifiers.

Method and standard references

ML-PEST updates a maximum-likelihood MT estimate after every recorded response and suggests the next whole-percent test intensity. The default response model is a cumulative Gaussian with spread equal to 7% of candidate MT. Computational 0% negative / 100% positive anchors are model assumptions and are not counted as delivered pulses.

The 20- and 30-pulse options are review checkpoints, not confidence-based stopping criteria. The curve shows relative likelihood, not a confidence interval; clinical validation of this implementation is pending.

Awiszus (2003) · threshold-hunting methodology ↗

Mishory et al. (2004) · ML-PEST motor-threshold assessment ↗

Ah Sen et al. (2017) · 20-pulse hand EMG study ↗

Copy your report

Clipboard access is unavailable. Select and copy the text below, or download it.